Quigg had surgery on his jaw after the only defeat of his 37-fight career at the hands of Frampton and relocated to Los Angeles early last year to work with trainer Freddie Roach.
He has won all three of his fights at featherweight.
Valdez, who has recorded 19 knockout victories, has defended his WBO title twice since beating Hiroshige Osawa to land the belt in November 2016.
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Scott Quigg vs Oscar Valdez Live
Sat, Mar 10 2018
Time : 10:30 pm ET
Quigg is a step up in opposition for Valdez.
Says promoter Bob Arum: “Oscar Valdez has passed every in-ring test with flying colors, but the biggest test of his professional career will be Quigg.
“Like Oscar, he rarely leaves a fight in the hands of the judges.”
Where is the WBO world featherweight title fight?
Quigg is in action at the StubHub Center in Carson, California, on Saturday, March 10.
Because of the time difference in the US, the fight will take place in the early hours of Sunday, March 11 UK time.
The fight is live on Sky Sports Main Event.
If you haven’t already, you can sign up to Sky TV here.
Or if you don’t want a subscription, you can buy a Now TV Day Pass for as little as £7.99 and watch all the action live. Buy it here.
Now TV also have a promotion on currently that lets you buy a month-long subscription for just £20 (normally £33.99).